Dr. Marc A. Pfeffer, a graduate of Rockford College in Rockford, Illinois, received both his doctorate in physiology and biophysics and his medical degree from the University of Oklahoma in Oklahoma City. He completed his internship, residency and clinical fellowship at the Peter Bent Brigham Hospital, Harvard Medical School in Boston. Dr. Pfeffer is currently the Dzau Professor of Medicine at Harvard Medical School and physician in the Cardiology Division at Brigham and Women’s Hospital.  Dr. Pfeffer also serves as medical director of Partners Research and Education Program (PREP)

        Dr. Pfeffer has distinguished himself as a translational investigator.  Along with his late wife, Dr. Janice Pfeffer, and Eugene Braunwald, M.D., their studies in an experimental model of myocardial infarction first introduced the concept of an insidious deleterious structural remodeling of the impaired ventricle.  They demonstrated in both animals and man that angiotensin converting enzyme (ACE) inhibitors could attenuate these adverse structural and functional changes providing the rationale for the use of these agents in patients experiencing a myocardial infarction.  Pfeffer led the first definitive clinical trial demonstrating that this use could prolong survival and prevent the development of heart failure, which has improved the prognosis of untold numbers of survivors of myocardial infarction.