TIMI Study Group
Brigham and Women’s Hospital
Harvard Medical School
Christian T. Ruff, MD, MPH is currently an Associate Physician in the Cardiovascular Division at Brigham and Women’s Hospital in Boston, MA and an Assistant Professor of Medicine at Harvard Medical School.
Dr. Ruff graduated Magna Cum Laude from Harvard University with a degree in Neurobiology, earned his medical degree with Alpha Omega Alpha honors at the Johns Hopkins University School of Medicine, and his masters of public health at the Harvard School of Public Health. Dr. Ruff completed his internal medicine residency and cardiovascular medicine fellowship at the Brigham and Women’s Hospital.
Dr. Ruff is an investigator in the Thrombolysis in Myocardial Infarction (TIMI) Study Group and serves the Director of the Genetics Core Laboratory and the Co-Chairman of the Clinical Events Committee. He has led a broad array of projects, ranging from investigator initiated studies of biomarkers and genetic variants to large clinical trials, including being the lead co-investigator for the ENGAGE AF-TIMI 48 study evaluating the factor Xa inhibitor edoxaban for the prevention of thromboembolism in patients with atrial fibrillation. Dr. Ruff has specific expertise in atrial fibrillation, both risk stratification and implementation of antithrombotic therapy for stroke prevention, as well as the treatment and prevention of venous thromboembolism. He has been selected to serve as the Chairman for the Stroke Prevention in Atrial Fibrillation Consensus Initiative for the North American Thrombosis Forum. He also has an interest in developing innovative computational and bioinformatic strategies to identify important relationships across genes, proteins, and compounds.
Dr. Ruff has given over a hundred lectures nationally and internationally, as well as authored many scholarly articles, editorials, reviews, and book chapters that include the New England Journal of Medicine, Lancet, Journal of the American Medical Association, American Journal of Medicine, Circulation, Journal of the American College of Cardiology, and Nature Reviews Cardiology.