Dr. Horton is a Professor of Internal Medicine and Molecular Genetics, Chief of the Division of Digestive and Liver Diseases, and holds the Robert C. and Veronica Atkins Chair in Obesity and Diabetes Research at UT Southwestern Medical Center at Dallas. He obtained his BS and MD degrees from the University of Iowa and completed his internal medicine residency, gastroenterology fellowship, and Howard Hughes post-doctoral fellowship at UT Southwestern Medical Center. Dr. Horton is a former PEW scholar and member of the American Society for Clinical Investigation and Association of American Physicians. He serves as a consulting editor for Arteriosclerosis, Thrombosis, and Vascular Biology and as an associate editor of The Journal of Lipid Research.
Dr. Horton's research interest lies in conditions that lead to fatty liver disease and obesity. Currently a major focus of the laboratory is to determine how regulators of fat metabolism contribute to the development of fatty liver in various disease processes such as diabetes, obesity, and fatty acid oxidation defects.
In recent work, Dr. Horton has delineated the function of PCSK9, a protein secreted into the blood that determines plasma cholesterol levels through its action on LDL receptors in the liver.