2018 Virtual Symposium: Updates in Inflammation and Secondary CVD Prevention

Healthcare professionals agree on aggressive therapy for secondary prevention of CVD with statins, the cornerstone of therapy; however, recent focus has been given to the role of inflammation in the initiation and progression of atherosclerosis, the main cause of CVD, and as a treatment target for patients at risk. Observational evidence and results from clinical trials with statins have demonstrated that a reduction in inflammatory biomarkers, e.g., C-reactive protein (CRP), is associated with a reduction in cardiovascular events. A recent clinical trial has affirmed the hypothesis that reducing vascular inflammation in the absence of concomitant lipid lowering reduces the rates of cardiovascular events and demonstrated a 15% reduction in cardiovascular events compared to placebo.

During this activity, Brendan M. Everett, MD and Ishwarlal Jialal, MD, PhD will provide an overview of the role of inflammation in the pathogenesis of atherosclerosis and atherothrombotic events and residual inflammatory risks in patients with CVD. The expert faculty will focus on the role of biomarkers in assessing secondary CVD risk and review the most recent clinical trial data from the completed CANTOS study and the ongoing CIRT trial. The activity will conclude with an interactive patient case moderated by Christie M. Ballantyne, MD to demonstrate a patient at risk for secondary CVD and how managing inflammation may potentially reduce that risk. Participants will also be given the opportunity to pose questions and interact with the expert faculty during this time to enhance their knowledge and clinical practice.

Role of Inflammation in the Pathogenesis of Atherosclerosis and Atherothrombotic Events: Biology and Pathogenesis

Presenter: Ishwarlal Jialal, MD, PhD

Residual Inflammatory Risks: From Biomarkers to Clinical Interventions

Presenter: Brendan M. Everett, MD

Interactive Patient Case Discussion

Chairperson: Christie M. Ballantyne, MD

Presenter: Brendan M. Everett, MDIshwarlal Jialal, MD, PhD

Conclusions and Q&A

Chairperson: Christie M. Ballantyne, MD

Presenter: Brendan M. Everett, MDIshwarlal Jialal, MD, PhD