Michael Honigberg, MD, MPP

Michael Honigberg, MD, MPP



Michael Honigberg, MD, MPP is a cardiologist-investigator in the Cardiology Division at Massachusetts General Hospital (MGH), Assistant Professor of Medicine at Harvard Medical School, and Associate Member of the Broad Institute of MIT and Harvard. He received his MD from Harvard Medical School and MPP from the Harvard Kennedy School of Government, trained in internal medicine at Brigham and Women’s Hospital, and completed clinical and research fellowship in cardiovascular medicine at MGH. Dr. Honigberg’s research integrates epidemiology, human genetics, multi-omics approaches, imaging, and community-based research to (1) elucidate sex-specific risk factors for cardiovascular disease in women (e.g., preeclampsia, premature age of menopause) and their underlying mechanisms, (2) improve cardiovascular risk prediction and allocation of existing and novel preventive therapies, and (3) define strategies to mitigate disparities in cardiovascular disease prevention. His recent work has focused on defining the cardiovascular consequences of preeclampsia and premature age of menopause, including defining germline and somatic genomic factors that contribute to heightened cardiovascular risk in affected women, and on the cardiovascular consequences of clonal hematopoiesis of indeterminate potential (CHIP), the clonal expansion of blood stem cells harboring pre-leukemic driver mutations. He recently led the largest genome-wide association study to date of preeclampsia and gestational hypertension (Nature Medicine 2023), yielding new insights into shared genetic risks with cardiovascular disease. His research program is supported by a K08 award from the National Heart, Lung, and Blood Institute, a career development award from the American Heart Association, and additional grants from the American Heart Association and Patient-Centered Outcomes Research Institute. Dr. Honigberg is the recipient of the Jeremiah Stamler Award from the Northwestern Cardiovascular Young Investigators’ Forum, the 2023 Douglas P. Zipes Distinguished Young Scientist Award from the American College of Cardiology, and the 2024 Young Physician-Scientist Award from the American Society for Clinical Investigation.

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